Dr. Guentchev received his M.D. and Ph.D. from the University of Vienna, Austria where he also completed his Residency in Neurosurgery. From 2001 to 2004 he went on to become a Visiting Fellow at National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD. Since 2011 he is Head of Unit at the Dept of Neurosurgery, Klinikum Idar-Oberstein, Germany, training hospital of the Johannes Gutenberg-University Mainz. Since 2015 Dr. Marin Guentchev is Ass. Professor (Privatdozent) at the University of Heidelberg, Germany.


Dr. Guentchev's professional interests include complex spinal surgery and pain treatment.


Dr. Guentchev's main research interests are focused on the molecular biology of primary brain tumours. Recent results from his research group were published 2014 in the peer reviewed journal Cancer. Further, Dr. Guentchev published a novel method for treating therapy resistant Sacroiliac Joint Pain via neurostimulation. These results were published in Neuromodulation the official journal of the International Neuromodulation Society.


For his research Dr. Guentchev received following scientific awards: 2014 DGNC Posterpreis Neuromodulation, 2002 Pfizer Österreich ZNS Preis, 2000 Pfizer Österreich ZNS Preis, 1999 Erste Bank Preis der Österreichischen Ärztekammer, 1998 EFNS Meeting, Poster Prise.


Guentchev M,  Preuss C,  Rink R, Peter L, Sailer M, Tuettenberg J. Long-Term Reduction of Sacroiliac Joint Pain With Peripheral Nerve Stimulation. Operative Neurosurgery, 2017 Oct;13(5):634–639.

Birner P, Tchorbanov A, Natchev S, Tuettenberg J, Guentchev M. The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner. J Clin Pathol. 2015 Oct;68(10):830-4.

Guentchev M, Preuss C, Rink R, Peter L, Wocker EL, Tuettenberg J. Technical Note: Treatment of Sacroiliac Joint Pain with Peripheral Nerve Stimulation. Neuromodulation. 2015 Jul;18(5):392-6.

Birner P, Pusch S, Christov C, Mihaylova S, Toumangelova-Uzeir K, Natchev S, Schoppmann SF, Tchorbanov A, Streubel B, Tuettenberg J, Guentchev M. Mutant IDH1 inhibits PI3K/Akt signaling in human glioma. Cancer. 2014 Aug 15;120(16):2440-7.


Birner P, Toumangelova-Uzeir K, Natchev S, Guentchev M. Expression of mutated isocitrate dehydrogenase-1 in gliomas is associated with p53 and EGFR expression. Folia Neuropathol. 2011;49(2):88-93.

Maresch J, Birner P, Zakharinov M, Toumangelova-Uzeir K, Natchev S, Guentchev M. Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma. Cancer. 2011 Jun 1;117(11):2499-504.


Birner P, Toumangelova-Uzeir K, Natchev S, Guentchev M. STAT3 tyrosine phosphorylation influences survival in glioblastoma. J Neurooncol. 2010 Dec;100(3):339-43.


Guentchev M, McKay RD. Notch controls proliferation and differentiation of stem cells in a dose-dependent manner. Eur J Neurosci. 2006 May;23(9):2289-96.


Kovacs GG, Gasque P, Ströbel T, Lindeck-Pozza E, Strohschneider M, Ironside JW, Budka H, Guentchev M. Complement activation in human prion disease. Neurobiol Dis. 2004 Feb;15(1):21-8.


Guentchev M, Siedlak SL, Jarius C, Tagliavini F, Castellani RJ, Perry G, Smith MA, Budka H. Oxidative damage to nucleic acids in human prion disease. Neurobiol Dis. 2002 Apr;9(3):275-81.


Wanschitz J, Klöppel S, Jarius C, Birner P, Flicker H, Hainfellner JA, Gambetti P, Guentchev M, Budka H. Alteration of the serotonergic nervous system in fatal familial insomnia. Ann Neurol. 2000 Nov;48(5):788-91.


Guentchev M, Voigtländer T, Haberler C, Groschup MH, Budka H. Evidence for oxidative stress in experimental prion disease. Neurobiol Dis. 2000 Aug;7(4):270-3.

Guentchev M, Wanschitz J, Voigtländer T, Flicker H, Budka H. Selective neuronal vulnerability in human prion diseases. Fatal familial insomnia differs from other types of prion diseases. Am J Pathol. 1999 Nov;155(5):1453-7.


Guentchev M, Groschup MH, Kordek R, Liberski PP, Budka H. Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies. Brain Pathol. 1998 Oct;8(4):615-23.


Guentchev M, Hainfellner JA, Trabattoni GR, Budka H. Distribution of parvalbumin-immunoreactive neurons in brain correlates with hippocampal and temporal cortical pathology in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol. 1997 Oct;56(10):1119-24.


Интервю с М. Зиновиева


в. Лечител


Нова Тв

Добрата болница трябва да може да прави пари


в. Стандарт


Защо неврохирург избра България пред Германия?


bTV, 120 минути


Новостите в гръбначната хирургия


Здравето отблизо, БНТ


Болката изчезва чрез невростимулация


в. Преса

Idar-Obersteiner entschlüsseln Krebs-Gen


Rhein Zeitung

Idar-Oberstein. Zwei Neurochirurgen aus Idar-Oberstein haben im Kampf gegen den Hirnkrebs einen Etappensieg erzielt. Nun besteht Hoffnung, in absehbarer Zeit ein wirkungsvolles Medikament gegen diese besonders aggressive Krebsart entwickeln und auch weitere Krebsvarianten besser behandeln zu können.

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